Motif ID: TFAP2{A,C}.p2

Z-value: 1.887


Transcription factors associated with TFAP2{A,C}.p2:

Gene SymbolEntrez IDGene Name
TFAP2A 7020 transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha)
TFAP2C 7022 transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)

Activity-expression correlation:

GenePromoterPearsonP-valuePlot
TFAP2Achr6_-_104152170.485.1e-14Click!
TFAP2Cchr20_+_55204307-0.063.7e-01Click!


Activity profile for motif TFAP2{A,C}.p2.

activity profile for motif TFAP2{A,C}.p2


Sorted Z-values histogram for motif TFAP2{A,C}.p2

Sorted Z-values for motif TFAP2{A,C}.p2



Network of associatons between targets according to the STRING database.



First level regulatory network of TFAP2{A,C}.p2

PNG image of the network

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Top targets:


Showing 1 to 20 of 200 entries
PromoterScoreRefseqGene SymbolGene Name
chr2_+_236403290 37.114 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr2_+_236402948 25.307 AGAP1
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
chr15_-_48937068 25.103 FBN1
fibrillin 1
chr17_-_74707000 23.220 NM_001008528
NM_001008529
NM_198530
 MXRA7


matrix-remodelling associated 7


chr17_-_7197811 21.344 YBX2
Y box binding protein 2
chr16_+_226678 20.902 NM_000558
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr17_-_7197896 20.513 YBX2
Y box binding protein 2
chr17_-_7197866 19.517 NM_015982
 YBX2
Y box binding protein 2
chr7_-_129251465 19.396


chr16_+_222845 17.520 NM_000517
 HBA1
HBA2
hemoglobin, alpha 1
hemoglobin, alpha 2
chr11_-_65640199 17.337 NM_016938
 EFEMP2
EGF containing fibulin-like extracellular matrix protein 2
chr8_-_48650683 15.834 CEBPD
CCAAT/enhancer binding protein (C/EBP), delta
chr9_-_112083005 15.282 NM_018424
NM_019114
 EPB41L4B

erythrocyte membrane protein band 4.1 like 4B

chr9_+_137533643 13.681 NM_000093
 COL5A1
collagen, type V, alpha 1
chr13_+_110959592 12.912 NM_001846
 COL4A2
collagen, type IV, alpha 2
chr3_-_124774735 12.821 NM_020733
 HEG1
HEG homolog 1 (zebrafish)
chr2_-_218843541 12.692 TNS1
tensin 1
chr17_-_74707066 12.489 MXRA7
matrix-remodelling associated 7
chr3_+_51428720 12.371 RBM15B
RNA binding motif protein 15B
chr15_+_96873845 11.858 NM_021005
 NR2F2
nuclear receptor subfamily 2, group F, member 2

Gene Ontology Analysis

Gene overrepresentation in process category:

Showing 1 to 20 of 384 entries
enrichment   p-value GO term description
2.15 4.69e-03 GO:0000070 mitotic sister chromatid segregation
2.14 2.25e-03 GO:0045767 regulation of anti-apoptosis
2.11 4.57e-02 GO:0045768 positive regulation of anti-apoptosis
2.07 2.37e-03 GO:0060070 canonical Wnt receptor signaling pathway
2.07 1.04e-02 GO:0000819 sister chromatid segregation
1.82 1.75e-02 GO:0031346 positive regulation of cell projection organization
1.82 3.91e-02 GO:0051147 regulation of muscle cell differentiation
1.79 2.65e-02 GO:0007173 epidermal growth factor receptor signaling pathway
1.74 1.88e-03 GO:0061138 morphogenesis of a branching epithelium
1.73 3.37e-05 GO:0000082 G1/S transition of mitotic cell cycle
1.71 1.87e-03 GO:0045792 negative regulation of cell size
1.71 4.07e-03 GO:0007611 learning or memory
1.71 3.47e-02 GO:0031397 negative regulation of protein ubiquitination
1.70 8.87e-03 GO:0006836 neurotransmitter transport
1.69 2.26e-03 GO:0050890 cognition
1.69 1.52e-02 GO:0010720 positive regulation of cell development
1.68 1.20e-02 GO:0030308 negative regulation of cell growth
1.67 4.03e-04 GO:0045926 negative regulation of growth
1.66 1.46e-03 GO:0016055 Wnt receptor signaling pathway
1.65 9.72e-03 GO:0033273 response to vitamin

Gene overrepresentation in compartment category:

Showing 1 to 20 of 78 entries
enrichment   p-value GO term description
1.88 1.87e-05 GO:0042470 melanosome
1.88 1.87e-05 GO:0048770 pigment granule
1.85 3.29e-03 GO:0031256 leading edge membrane
1.69 7.67e-03 GO:0000776 kinetochore
1.67 1.16e-02 GO:0001726 ruffle
1.63 7.36e-06 GO:0031252 cell leading edge
1.60 1.21e-03 GO:0000793 condensed chromosome
1.60 3.65e-02 GO:0005925 focal adhesion
1.58 3.07e-02 GO:0030055 cell-substrate junction
1.58 3.99e-02 GO:0005924 cell-substrate adherens junction
1.57 1.68e-04 GO:0030424 axon
1.57 1.41e-02 GO:0044455 mitochondrial membrane part
1.55 4.48e-04 GO:0005819 spindle
1.54 7.32e-03 GO:0000775 chromosome, centromeric region
1.52 2.62e-02 GO:0031301 integral to organelle membrane
1.48 5.66e-08 GO:0043005 neuron projection
1.48 2.57e-02 GO:0031300 intrinsic to organelle membrane
1.47 6.33e-03 GO:0030425 dendrite
1.43 5.43e-04 GO:0015629 actin cytoskeleton
1.43 8.21e-03 GO:0016604 nuclear body

Gene overrepresentation in function category:

Showing 1 to 20 of 49 entries
enrichment   p-value GO term description
1.76 4.93e-03 GO:0019199 transmembrane receptor protein kinase activity
1.69 4.18e-02 GO:0031625 ubiquitin protein ligase binding
1.67 7.31e-03 GO:0005057 receptor signaling protein activity
1.62 6.93e-04 GO:0003714 transcription corepressor activity
1.62 1.83e-02 GO:0019838 growth factor binding
1.55 1.74e-04 GO:0019901 protein kinase binding
1.53 9.02e-06 GO:0032403 protein complex binding
1.52 6.11e-07 GO:0016563 transcription activator activity
1.51 1.77e-04 GO:0019900 kinase binding
1.48 3.59e-07 GO:0000988 protein binding transcription factor activity
1.48 3.59e-07 GO:0000989 transcription factor binding transcription factor activity
1.48 5.38e-07 GO:0003712 transcription cofactor activity
1.46 1.62e-04 GO:0008134 transcription factor binding
1.46 9.76e-03 GO:0000975 regulatory region DNA binding
1.46 9.76e-03 GO:0001067 regulatory region nucleic acid binding
1.46 9.76e-03 GO:0044212 transcription regulatory region DNA binding
1.46 1.64e-02 GO:0010843 promoter binding
1.46 2.74e-02 GO:0003682 chromatin binding
1.45 1.32e-13 GO:0019899 enzyme binding
1.45 4.38e-07 GO:0019904 protein domain specific binding